Bipolar disorder

Bipolar disorder is a mood disorder characterized as alternating between depressive episodes and hypomanic or manic episodes. It is also called manic depression.

Bipolar I disorder occurs when a manic episode has occurred; otherwise, it is only considered bipolar II disorder.

Depressed moods include feeling: sad, low, blue, empty, hopeless, anhedonic, or irritable.

Manic/hypomanic moods include feeling: euphoric, elevated, expansive, or irritable.

DSM-5 diagnostic criteria

Bipolar I

Requirements:
- One manic episode
- No need for hypomanic or depressive episodes
- (Mania typically followed by depression, but depressive episode no longer required in DSM-5)
Diagnostic coding elaborate
- Current or most recent episode (MRE): manic, hypomanic, or depressed?
- Severity: mild, moderate, severe, or with psychotic features
Specifiers with
- Anxious distress
- Mixed features
- Rapid cycling - 4 or more mood changes in a year
- Melancholic features
- Atypical features
- Mood-congruent psychotic features
- Mood-incongruent psychotic features
- Catalonia
- Peripartum onset (postpartum)
- Seasonal pattern (seasonal affective disorder)

Bipolar II

Requirements
- One hypomanic episode (or more) AND
- One depressive episode (or more) AND
- No manic episodes

Depressive episode

A depressive episode is defined as the following:

Criterion A: Need to satisfy 5 or more of 9 symptoms
- For at least two weeks and represent a change from previous functioning (observably)
- (1) Depressed mood, most of the day, nearly every day
- (2) Markedly diminished interest or pleasure in all or almost all activities most of the day nearly every day
- Primary mood criterion - one symptom must be either (1) or (2) - i.e. must be either depressed mood or loss of interest/pleasure
- (3) Significant weight gain/loss - decrease/increase in appetite almost every day
  - Around 5% weight change in a month’s time
- (4) Insomnia or hypersomnia nearly every day
  - Lack of sleep or sleeping too much
- (5) Psychomotor agitation/retardation nearly every day, observable by others (not just subjective feelings or restlessness or being slowed down)
  - Either being slowed down or feeling agitated
- (6) Fatigue or loss of energy nearly every day
  - have trouble moving around
- (7) Feelings of worthlessness or excessive/inappropriate guilt nearly every day
- (8) Difficult to think/can’t concentrate or indecisiveness every day
  - If student has trouble focusing in class, it might be depression instead of ADHD
- (9) Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation without a specific plan, or a suicide attempt, or a specific plan for committing suicide
Criterion B - the symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning
- Some part of your life feels like it’s falling apart
- Getting in the way of how you live your life
Criterion C - the episode is not attributable to the physiological effects of a substance or another medical condition
- For instance, diabetes might cause depressive symptoms
- These need to be ruled out before depressive episode

Hypomanic episode

Criterion A - distinct period of abnormally and persistently elevated, expansive, or irritable mood AND abnormally and persistently increased activity or energy, lasting at least 4 consecutive days and present most of the day, nearly every day
Criterion B - during the period of mood disturbance and increased energy/activity, [3 (or more) of the following symptoms if expansive, 4 if the mood is only irritable] have persisted, represent a noticeable change from usual behavior, and have been present to a significant degree:
- (1) Inflated self-esteem or grandiosity
  - Full of yourself
- (2) Decreased need for sleep
- (3) More talkative than usual or pressure to keep talking
- (4) Flight of ideas or thoughts racing
  - Expression of ideas in speech are not logically connected well
- (5) Distractibility (reported or observed)
- (6) Big increase in goal-directed activity (either socially, at work or school, or sexually) or psychomotor agitation
- (7) Excessive involvement in activities that have a high potential for painful consequences (unrestrained buying sprees, sexual indiscretions, foolish business investments)
Criterion C - The episode is associated with an unequivocal change in functioning that is uncharacteristic of the individual when not symptomatic
Criterion D - The disturbance in mood and change in functioning are observable by others
Criterion E - The episode is NOT severe enough to cause marked impairment in social or occupational functioning or necessitate hospitalization. If there are psychotic features, the episode is, by definition, manic.
Criterion F - The episode is not attributable to the physiological effects of a substance
- Coffee, nicotine, ADHD medications, cocaine, etc.

Manic episode

Criterion A - a distinct period of abnormally and persistently elevated, expansive, or irritable mood AND abnormally and persistently increased goal-directed activity or energy, lasting at least one week (as opposed to 4 days in hypomanic episodes) and present most of the day, nearly every day (or for any duration if hospitalization is necessary - no one week requirement)
Criterion B - 3 of 7 symptoms, 4 of 7 if only irritable - at a level more extreme than hypomania
- (1) Inflated self-esteem or grandiosity
  - Full of yourself
- (2) Decreased need for sleep
- (3) More talkative than usual or pressure to keep talking
- (4) Flight of ideas or thoughts racing
  - Expression of ideas in speech are not logically connected well
- (5) Distractibility (reported or observed)
- (6) Big increase in goal-directed activity (either socially, at work or school, or sexually) or psychomotor agitation
- (7) Excessive involvement in activities that have a high potential for painful consequences (unrestrained buying sprees, sexual indiscretions, foolish business investments)
Criterion C - the mood disturbance is sufficiently severe to cause marked impairment in social or occupational functioning or to necessitate hospitalization to prevent harm to self or others, or there are psychotic features
Criterion D - The episode is not attributable to the physiological effects of a substance or to another medical condition

Medication

Bipolar patients typically respond badly to SSRIs and SNRIs; as a result, they should not be administered. Instead, mood stabilizers and antipsychotics such as Abilify, Seroquel, and lithium tend to be good medications for managing bipolar disorder.

Other info

Those with bipolar disorder tend to have higher creativity.